1282935-04-9Relevant academic research and scientific papers
Ago-allosteric modulators of human glucagon-like peptide 2 receptor
Yamazaki, Kazuto,Terauchi, Hiroki,Iida, Daisuke,Fukumoto, Hironori,Suzuki, Shuichi,Kagaya, Takaki,Aoki, Mika,Koyama, Koichiro,Seiki, Takashi,Takase, Kazuma,Watanabe, Misako,Arai, Tohru,Tsukahara, Kappei,Nagakawa, Junichi
, p. 6126 - 6135 (2012/10/30)
Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor (GPCR). Few synthetic agonists have been reported so far for class-B GPCRs. Here, we report the first scaffold compounds of ago-allosteric modulators for human GLP-2R, derived from methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino) ethyl]sulfanyl}benzoate (compound 1).
