128298-81-7

Basic information

• Product Name: (2S,4S)-2-hydroxy-4-tert-butylcyclohexanone
• CAS NO: 128298-81-7
• Molecular Weight: 170.252
• Mol File: 128298-81-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2S,4S)-2-hydroxy-4-tert-butylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-2-hydroxy-4-tert-butylcyclohexanone(128298-81-7)
• EPA Substance Registry System: (2S,4S)-2-hydroxy-4-tert-butylcyclohexanone(128298-81-7)

Safety Data

• Hazardous Substances Data: 128298-81-7(Hazardous Substances Data)

Upstream product

• 57466-12-3 4-tert-butyl-1-methoxycyclohexene 
• 100190-34-9 (S)-4-tert-butyl-1-(trimethylsilyloxy)cyclohexene 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 7360-39-6 1-acetoxy-4-tert-butylcyclohexene 
• 37720-52-8 4-tert.-Butyl-2-hydroperoxy-cyclohex-3-en-1-on 
• 5234-62-8 4-tert.-Butyl-cyclohex-3-en-1-on 
• 19980-19-9 4-t-butyl-1-trimethylsilyloxy-1-cyclohexene 
• 1076-82-0 cis-4-tert-Butyl-2-bromocyclohexanone 

Downstream Products

• 128226-87-9 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1R,5R)-5-tert-butyl-2-oxo-cyclohexyl ester 
• 128658-62-8 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,5S)-5-tert-butyl-2-oxo-cyclohexyl ester 

Relevant articles and documents

Preparation of α-oxygenated ketones by the dioxygenation of alkenyl boronic acids

Two in two: Dioxygenation of alkenyl boronic acids has been achieved with N-hydroxyphthalimide. The two-step process involves etherification of an alkenyl boronic acid with N-hydroxyphthalimide followed by a [3,3] rearrangement. The dioxygenated product can then be hydrolyzed to form either the corresponding α-hydroxy ketone or the α-benzoyloxy ketone. Copyright

Synthesis of α-hydroxy ketones using a HOF·MeCN complex

The complex, HOF·MeCN made directly by bubbling fluorine through aqueous acetonitrile, reacts quickly and efficiently with enolic forms of ketones to produce α-hydroxy ketones.

Chiral products via asymmetric deprotonation of 4-tert-butylcyclohexanone using chiral lithium amide bases

The asymmetric deprotonation of 4-tert-butylcyclohexanone using chiral lithium amide bases gives derived silyl enol ether products in up to 88% ee.