1283068-47-2Relevant academic research and scientific papers
Titanium-mediated oxidative arylation of homoallylic alcohols
Lee, Kathleen S.,Ready, Joseph M.
, p. 2111 - 2114 (2011)
E-Substituted styrene derivatives are synthesized from terminal olefins and aryl Grignard reagents through TiIV-mediated oxidative coupling (see scheme). Substrates include homoallylic alcohols containing a range of functional groups and substituted aryl Grignard reagents. The reaction may proceed through aryltitanation followed by β-hydride elimination; reductive elimination of arene occurs from a TiIVH(aryl) intermediate.
