1283155-61-2Relevant academic research and scientific papers
C2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of β-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals
Yang, Zhen-Yan,Zeng, Jun-Liang,Ren, Nan,Meng, Wei,Nie, Jing,Ma, Jun-An
supporting information, p. 6364 - 6367 (2016/12/23)
A simple C2-symmetric chiral bisoxazoline is demonstrated to use hydrogen bonding to catalyze an important family of aldol reactions of trifluoroacetaldehyde hemiacetals with various β-carbonyl acids. This reaction is highly enantioselective, delivering chiral nonracemic trifluoromethylated alcohols with excellent optical purity and good isolated yields. This concept of relaying chiral information via a chiral hydrogen-bond acceptor should be applicable to a vast number of organocatalytic processes.
Copper-catalyzed one-pot denitrogenative-dehydrogenative-decarboxylative coupling of β-ketoacids with trifluorodiazoethane: Facile access to trifluoromethylated aldol products
Xiong, Heng-Ying,Yang, Zhen-Yan,Chen, Zhen,Zeng, Jun-Liang,Nie, Jing,Ma, Jun-An
supporting information, p. 8325 - 8329 (2014/07/08)
A novel copper-catalyzed one-pot cross-coupling of β-ketoacids with in situ generated trifluorodiazoethane has been developed. This reaction provides a direct and efficient method, in which one C-C bond and one C-O bond were formed in a carbenoid center with concomitant denitrogenation-dehydrogenation- decarboxylation, to afford trifluoromethylated aldol products. In several preliminary experiments, good to high enantioselectivities were also obtained.
Organocatalytic asymmetric direct aldol reactions of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones
Funabiki, Kazumasa,Itoh, Yuya,Kubota, Yasuhiro,Matsui, Masaki
experimental part, p. 3545 - 3550 (2011/06/22)
The organocatalytic asymmetric direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 °C proceeds smoothly to produ
