128316-75-6Relevant academic research and scientific papers
Candida antarctica lipase B catalyzed enantioselective acylation of pyrimidine acyclonucleoside
Kolodziejska, Renata,Karczmarska-Wodzka, Aleksandra,Draminski, Marcin,Wolan, Andrzej
, p. 426 - 430,5 (2020/09/09)
The influence of solvent and acyl group donor on selectivity of the transesterification reaction of 1-[1′,3′-dihydroxy-2′- propoxymethyl]-5-methyluracil, a structural analogue of ganciclovir was examined. Lipase (EC 3.1.1.3) B from Candida antarctica (CAL
Effect of various pyrimidines possessing the 1-[(2-hydroxy-1- (hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2′- deoxyribose, on wild-type and mutant hepatitis B virus replication
Kumar, Rakesh,Semaine, Wassila,Johar, Monika,Tyrrell, D. Lorne J.,Agrawal, Babita
, p. 3693 - 3700 (2007/10/03)
Hepatitis B virus (HBV) is the most common cause of chronic liver disease worldwide. Development of drug resistance against clinical anti-HBV drug lamivudine due to long-term use and rebound of viral DNA after cessation of treatment has been a major setba
EFFICIENT SYNTHESIS OF 1,2-seco AND 1,2-seco 2-nor PYRIMIDINE AND PURINE NUCLEOSIDES.
Azymah, Muhammad,Chavis, Claude,Lucas, Marc,Imbach, Jean-Louis
, p. 6165 - 6168 (2007/10/02)
Unprotected sylilated purines and pyrimidines (adenine, guanine, cytosine, thymine) reacted with acetoxymethyl ether (acyclic sugar analogues) under solid PTC conditions, using KI and dibenzo-18-crown-6 in benzene-acetonitrile(1:1, v/v) to give regiospecifically the corresponding N-9 purine and N-1 pyrimidine acyclic nucleosides in fairly good yields.
