128318-72-9Relevant academic research and scientific papers
Highly efficient diastereoselective reduction of α-fluoroimines
Malamakal, Roy M.,Hess, Whitney R.,Davis, Todd A.
, p. 2186 - 2189 (2010)
A highly selective reduction of α-fluoroimines to the corresponding β-fluoroamines has been developed utilizing trichlorosilane as the reductant. The key aspect of this reaction is the ability of fluorine and nitrogen to activate organosilanes leading to high diastereoselectivity (>100:1) in the product distribution. This new method provides a new avenue for the diastereoselective synthesis of β-fluorinated amines in good yields and selectivity.
SYNTHESE DE β-FLUOROAMINES
Toulgui, Ch.,Chaabouni, M. M.,Baklouti, A.
, p. 385 - 391 (2007/10/02)
β-Fluoroamine compounds were obtained from 2-fluorotosylates by action of an excess of amines in dimethyl sulfoxide.The substitution of the tosyl group by amine takes place in all the studied cases whereas the elimination of toluene-p-sulphonic acid (HOTs) is not observed.This process is a good general method for the synthesis of primary, secondary and tertiary β-fluoroamines in acceptable yields.
