128329-73-7

Upstream product

• 128329-72-6 5-(phenylmethoxy)pentanoic acid chloride 
• 80697-99-0 (S)-3-((R)-3-Benzyloxy-2-methyl-propionyl)-4-isopropyl-oxazolidin-2-one 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 

Downstream Products

• 250679-47-1 3-(5-benzyloxy-2S-methyl-1-oxopentyl)-4S-(methylethyl)-2-oxazolidinone 
• 128329-74-8 (+)-(4S,6'E)-3-(2'-(3''-(benzyloxy)propyl)-3'-hydroxy-6'-methyl-6'-octenoyl)-4-isopropyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Dual Activation of Unsaturated Amides with Schwartz's Reagent: A Diastereoselective Access to Cyclopentanols and N,O-Dimethylcyclopentylhydroxylamines.

The diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines from 4-pentenoic acid-derived Weinreb amides is described. Based on the concomitant generation of both the nucleophilic and the electrophilic poles by hydrozirconati

EPOTHILONE ANALOGUES

Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the aromatic side-chain.

Intermediates for the synthesis of epothilones and methods for their preparation

The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3and X4are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.