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1283372-48-4

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1283372-48-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1283372-48-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,3,3,7 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1283372-48:
(9*1)+(8*2)+(7*8)+(6*3)+(5*3)+(4*7)+(3*2)+(2*4)+(1*8)=164
164 % 10 = 4
So 1283372-48-4 is a valid CAS Registry Number.

1283372-48-4Relevant articles and documents

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold

Zhao, Ailing,Gao, Xin,Wang, Yuanxiang,Ai, Jing,Wang, Ying,Chen, Yi,Geng, Meiyu,Zhang, Ao

scheme or table, p. 3906 - 3918 (2011/08/06)

A series of thieno[2,3-d]pyrimidines and furo[2,3-d]pyrimidines were synthesized and evaluated for the c-Met inhibition. Thieno[2,3-d]pyrimidine 6b stood out as the most potent showing an IC50 of 35.7 nM. This compound displayed high inhibitory effect on cell proliferation in BaF3-TPR-Met cells and showed high selectivity for c-Met family against other 14 tested kinases. However, compound 6b was found ineffective in the c-Met-dependent U-87MG human gliobastoma xenograft model that may be relevant to its poor PK profile.

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