1283481-91-3Relevant academic research and scientific papers
Fluorinated DF508-CFTR correctors and potentiators for PET imaging
Davison, Holly R.,Solano, Danielle M.,Phuan, Puay-Wah,Verkman,Kurth, Mark J.
, p. 1602 - 1605 (2012/04/10)
19F-modified bithiazole correctors and phenylglycine potentiators of the DF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human DF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomography (PET). The DF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds.
