128349-88-2

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 29546-14-3 4-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-N,N-dimethylaniline 
• 91671-38-4 1-<4-(N,N-dimethylamino)phenyl>-1-pentanol 
• 15024-12-1 phenyl 4-(N,N-dimethylamino)benzoate 
• 308796-10-3 (1-pentyl)zinc(II) bromide 

Relevant academic research and scientific papers

Nickel-Catalyzed C-O Bond-Cleaving Alkylation of Esters: Direct Replacement of the Ester Moiety by Functionalized Alkyl Chains

Two efficient protocols for the nickel-catalyzed aryl-alkyl cross-coupling reactions using esters as coupling components have been established. The methods enable the selective oxidative addition of nickel to acyl C-O and aryl C-O bonds and allow the aryl-alkyl cross-coupling via decarbonylative bond cleavage or through cleavage of a C-O bond with high efficiency and good functional group compatibility. The protocols allow the streamlined, unconventional utilization of widespread ester groups and their precursors, carboxylic acids and phenols, in synthetic organic chemistry.

Novel routes to 4-substituted N,N-dialkylanilines, N-alkylanilines and anilines

4-(Benzotriazol-1-ylmethyl)-N,N-dialkylanilines, -N-alkylanilines, -anilines and some substituted analogs obtained via lithiation are converted by lithium aluminum hydride or Grignard reagents into 4-substituted N,N-dialkylanilines, N-alkylanilines and anilines, respectively, in good yields.

Reduction of Monobenzylic Alcohols with Sodium Borohydride/Trifluoroacetic Acid

Sodium borohydride/trifluoroacetic acid readily effects the reduction of monobenzylic alcohols to afford the corresponding hydrocarbons in moderate to high yields.