128350-75-4

Upstream product

• 7214-52-0 3,5-dimethyl-cyclohexanone 
• 108-24-7 acetic anhydride 
• 142130-93-6 ((3R,5S)-3,5-Dimethyl-cyclohex-1-enyloxy)-trimethyl-silane 

Relevant academic research and scientific papers

Enantioselective Formation of cis-3,5-Dimethylcyclohexanone Lithium Enolate and Stereoselective Aldol Reaction with Benzaldehyde

Deprotonation of cis-3,5-dimethylcyclohexanone (6) with chiral lithium amide bases 10-12 has been investigated.The resulting lithium enolates 7a,b react with benzaldehyde, acetic anhydride, or trimethylsilyl chloride to yield, respectively, the aldols 8 a

ENANTIOSELECTIVE DEPROTONATION OF THE MESO-FORMS OF 2,6- AND 3,5-DIMETHYLCYCLOHEXANONES

Kinetic deprotonation of meso-dimethylcyclohexanones (1a-c) by chiral lithium amides (2a-c) in the presence of excess trimethylsilyl chloride afforded the corresponding silyl enol ethers (3a-b) in good yields and in reasonably high enantiomeric excesses.