1283526-92-0

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 233276-38-5 4-methyltetrahydro-2H-pyran-4-carboxylic acid 
• 97302-05-1 di-4-methoxyphenylzinc 
• 696-62-8 para-iodoanisole 
• 66299-88-5 4-bromo-4-methyltetrahydro-2H-pyrane 
• 1023937-37-2 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ol 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 1283526-96-4 2-methoxy-5-(4-methyltetrahydro-2H-pyran-4-yl)-3-nitrobenzaldehyde 

Relevant academic research and scientific papers

Quaternary Centers by Nickel-Catalyzed Cross-Coupling of Tertiary Carboxylic Acids and (Hetero)Aryl Zinc Reagents

This work bridges a gap in the cross-coupling of aliphatic redox-active esters with aryl zinc reagents. Previously limited to primary, secondary, and specialized tertiary centers, a new protocol has been devised to enable the coupling of general tertiary systems using nickel catalysis. The scope of this operationally simple method is broad, and it can be used to simplify the synthesis of medicinally relevant motifs bearing quaternary centers.

Ni-Catalyzed Reductive Coupling of Electron-Rich Aryl Iodides with Tertiary Alkyl Halides

This work illustrates the reductive coupling of electron-rich aryl halides with tertiary alkyl halides under Ni-catalyzed cross-electrophile coupling conditions, which offers an efficient protocol for the construction of all carbon quaternary stereogenic centers. The mild and easy-to-operate reaction tolerates a wide range of functional groups. The utility of this method is manifested by the preparation of cyclotryptamine derivatives, wherein successful incorporation of 7-indolyl moieties is of particular interest as numerous naturally occurring products are composed of these key scaffolds. DFT calculations have been carried out to investigate the proposed radical chain and double oxidative addition pathways, which provide useful mechanistic insights into the part of the reaction that takes place in solution.

2,3-DIHYDRO-1H-INDENE-2-YL UREA DERIVATIVE AND PHARMACEUTICAL APPLICATION OF SAME

A 2,3-dihydro-1H-indene-2-yl urea derivative represented by Formula (Ia) or a pharmaceutically acceptable salt thereof: