1283594-59-1

Upstream product

• 99-91-2 para-chloroacetophenone 
• 1400691-41-9 C₁₀H₈ClF₃O₃ 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 331238-93-8 ADC₁₁₃ 

Downstream Products

• 1283594-83-1 (E)-1-(4-chlorophenyl)-2,2-difluoro-3-hydroxyoct-4-en-1-one 
• 1338328-40-7 2-bromo-1-(4-chlorophenyl)-2,2-difluoroethan-1-one 
• 1401081-96-6 2,2,4,4,4-pentafluoro-3-hydroxy-3-phenyl-1-(4-chlorophenyl)butan-1-one 
• 655-54-9 1-(4-chlorophenyl)-2,2-difluoropent-4-en-1-ol 
• 1268021-55-1 2-(4-chlorophenyl)-2-oxo-N-phenylacetamide 
• 1616792-22-3 1-(4-chlorophenyl)-2,2-difluoro-2-(2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone 

Relevant academic research and scientific papers

Synthesis of α,α-difluorobenzoyl oxygen heterocycles via the radical reaction of 2-iodo-2,2-difluoroacetophenones with unsaturated acids or unsaturated alcohols

A convenient and facile method for the direct synthesis of α,α-difluorobenzoyl lactones or cyclic ethers via the radical cyclization reaction of 2-iodo-2,2-difluoroacetophenone with unsaturated acids or alcohols was reported.

Agonists of the γ-aminobutyric acid type B (GABAB) receptor derived from β-hydroxy and β-amino difluoromethyl ketones

β-Hydroxy difluoromethyl ketones represent the newest class of agonists of the GABA-B receptor, and they are structurally distinct from all other known agonists at this receptor because they do not display the carboxylic acid or amino group of γ-aminobuty

Palladium-Catalyzed Benzodifluoroalkylation of Alkynes: A Route to Fluorine-Containing 1,1-Diarylethylenes

A palladium(0)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes and arylboronic acids is introduced for the synthesis of 1-benzoyldifluoromethyl-2,2-diphenylethylenes in good yields and with excellent stereoselectivity. The

Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor

The design, synthesis, biological evaluation, and in vivo studies of difluoromethyl ketones as GABAB agonists that are not structurally analogous to known GABAB agonists, such as baclofen or 3-aminopropyl phosphinic acid, are present

COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME

The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.

Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: Generation of α,α-difluoroenolates for aldol reactions

The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups.