1283594-81-9Relevant academic research and scientific papers
Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor
Han, Changho,Salyer, Amy E.,Kim, Eun Hoo,Jiang, Xinyi,Jarrard, Rachel E.,Powers, Matthew S.,Kirchhoff, Aaron M.,Salvador, Tolani K.,Chester, Julia A.,Hockerman, Gregory H.,Colby, David A.
, p. 2456 - 2465 (2013/05/22)
The design, synthesis, biological evaluation, and in vivo studies of difluoromethyl ketones as GABAB agonists that are not structurally analogous to known GABAB agonists, such as baclofen or 3-aminopropyl phosphinic acid, are present
COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME
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Page/Page column 30, (2012/10/08)
The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.
Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: Generation of α,α-difluoroenolates for aldol reactions
Han, Changho,Kim, Eun Hoo,Colby, David A.
, p. 5802 - 5805 (2011/05/19)
The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups.
