1283594-97-7Relevant academic research and scientific papers
Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes
Liu, Yang,Zhou, Yuhan,Zhao, Yilong,Qu, Jingping
, p. 946 - 949 (2017)
The first ferrous chloride catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes is described. Thus, a full range of gem-difluoroallylboronates were obtained in high yield under mild conditions. As an important fluorinated building block, gem-difluoroallylboronate can be readily converted into diverse difluoro-substituted species.
Fluorine-containing GABAB regulator synthesis method
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Paragraph 0019; 0024; 0035-0039, (2021/09/08)
The invention relates to a fluorine-containing GABAB regulator synthesis method. The preparation method comprises the steps: firstly using a compound (1) as a raw material, and carrying out an iodination reaction to prepare an intermediate product (2); and then taking the intermediate product (2) prepared in the step S1 and p-acetylbenzaldehyde as raw materials, and carrying out Reformatsky reaction under metal mediation to obtain the GABAB regulator racemate (3). Compared with the prior art, the method has the advantages of higher yield, mild reaction conditions, simple preparation method, simplicity and convenience in operation, green solvent, environment friendliness and the like, and thus, has a very good industrial application prospect.
Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters
Sasaki, Shigeru,Suzuki, Tatuo,Uchiya, Toshihiro,Toyota, Shigenobu,Hirano, Akira,Tanemura, Mao,Teramoto, Hiroyoshi,Yamauchi, Takayasu,Higashiyama, Kimio
, p. 78 - 85 (2016/11/09)
We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc?=?tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hy
Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor
Han, Changho,Salyer, Amy E.,Kim, Eun Hoo,Jiang, Xinyi,Jarrard, Rachel E.,Powers, Matthew S.,Kirchhoff, Aaron M.,Salvador, Tolani K.,Chester, Julia A.,Hockerman, Gregory H.,Colby, David A.
, p. 2456 - 2465 (2013/05/22)
The design, synthesis, biological evaluation, and in vivo studies of difluoromethyl ketones as GABAB agonists that are not structurally analogous to known GABAB agonists, such as baclofen or 3-aminopropyl phosphinic acid, are present
COMPOSITIONS AND PROCESSES OF PREPARING AND USING THE SAME
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Page/Page column 30; 31, (2012/10/08)
The present invention relates to compositions, for example, the DBU/Hexafluoroacetone hydrate salt, and processes of preparing and using the same for the modification of chemical compounds via the release of trifluoroacetate. The DBU/Hexafluoroacetone hydrate salt can perform trifluoromethylation reactions on chemical compounds, such as carbonyl group-containing compounds.
Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: Generation of α,α-difluoroenolates for aldol reactions
Han, Changho,Kim, Eun Hoo,Colby, David A.
supporting information; experimental part, p. 5802 - 5805 (2011/05/19)
The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups.
