1283594-99-9Relevant academic research and scientific papers
Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: Generation of α,α-difluoroenolates for aldol reactions
Han, Changho,Kim, Eun Hoo,Colby, David A.
, p. 5802 - 5805 (2011)
The selective cleavage of carbon-carbon bonds is a significant challenge in synthetic chemistry, yet this strategy can be a powerful way to generate reactive intermediates. We have discovered that, through the facile release of trifluoroacetate which occurs by C-C bond scission, difluoroenolates can be generated under very mild reaction conditions. Unlike existing reactions, this method is not limited to a small group of fluorinated building blocks. We have applied this process to the aldol reaction to install difluoromethylene groups.
