1283658-79-6

Basic information

• Product Name: 4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
• Synonyms: NHS-PEG8-amide-Br;BrCH2CONH-PEG8-NHS ester;2,5-dioxopyrrolidin-1-yl 1-bromo-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oate;4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
• CAS NO: 1283658-79-6
• Molecular Formula: C25H43BrN2O13
• Molecular Weight: 659.5185
• Mol File: 1283658-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester(1283658-79-6)
• EPA Substance Registry System: 4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester(1283658-79-6)

Safety Data

• Hazardous Substances Data: 1283658-79-6(Hazardous Substances Data)

Upstream product

• 756526-04-2 1-amino-3,6,9.12,15,18,21,24-octaoxaheptacosan-27-oic acid 
• 42014-51-7 bromoacetic acid N-hydroxusuccinimidyl ester 

Relevant articles and documents

NEW MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY

The invention relates to a compound of formula (I): wherein : ? ALK is a (C1-C6)alkylene group; ? X1 et X2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O)n (n=0,1 or 2) or O-; ? R and R' are independently H or a (C1-C6)alkyl group; ? I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; ? j is an integer corresponding to 1 when X2 is -CH=CH- and 2 when X2 is not -CH=CH-; ? Zb is a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.