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128366-50-7

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128366-50-7 Usage

Uses

A metabolite of Medetomidine (M203250).

Check Digit Verification of cas no

The CAS Registry Mumber 128366-50-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,3,6 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128366-50:
(8*1)+(7*2)+(6*8)+(5*3)+(4*6)+(3*6)+(2*5)+(1*0)=137
137 % 10 = 7
So 128366-50-7 is a valid CAS Registry Number.

128366-50-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-[1-(1H-imidazol-5-yl)ethyl]-2-methylphenyl]methanol

1.2 Other means of identification

Product number -
Other names 3-Hydroxy Medetomidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128366-50-7 SDS

128366-50-7Relevant articles and documents

Synthesis of detomidine and medetomidine metabolites: 1,2,3- Trisubstituted arenes with 4'(5')-imidazolylmethyl groups

Stoilov,Watt,Goodman,St. Pyrek

, p. 1645 - 1652 (2007/10/02)

Two synthetic strategies permitted the synthesis of various metabolites of detomidine (1) and medetomidine (4), potent α-2 adrenoceptor agonists that undergo rapid oxidative metabolism at the aromatic methyl group distal to the imidazole ring. In the detomidine series, the addition of a Grignard reagent prepared from 2-((3',4'-dimethoxyphenyl)methoxy)methyl-6-bromotoluene (13) to imidazole-4(5)-carboxaldehyde (7) provided 2-(((3',4'- dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'-(5''- imidazolyl)methyl)toluene (14). In a subsequent reduction, it was possible to differentiate between the secondary benzylic hydroxyl group and the primary benzylic hydroxyl group protected as a 3,4-dimethoxybenzyl ether. Removal of the protecting group provided 3-(hydroxymethyl)detomidine (3-HD) (2) and an oxidation furnished 3-carboxydetomidine (3-CD) (3). However, in the medetomidine series, a similar hydrogenolysis of 2-(((3',4'- dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'-methyl-1'-(5''- imidazolyl)methyl)toluene (17) failed, and an alternate, longer route involving dehydration and reduction was necessary to secure 3- (hydroxymethyl)medetomidine (3-HM) (5) and following an oxidation, 3- carboxymedetomidine (3-CM) (6). Finally, an expeditious route to 3-CM (6) involved the addition of the Grignard reagent prepared from 2-(3-bromo-2- methylphenyl)-4,4-dimethyl-2-oxazoline (22) to 4-acetyl-1H-imidazole and the hydrogenolysis and hydrolysis of 2-(1-(4,4-dimethyl-2-oxazolyl))-6-(1'-oxo- 1'-(5'-imidazolyl)methyl)toluene (23).

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