1283679-05-9

Upstream product

• 33305-10-1 ethyl thiazolidine-2-carboxylate 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 

Downstream Products

• 1041609-17-9 3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-benzylthiazolidine-2-carboxamide hydrochloride 
• 1041609-59-9 3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-((furan-3-yl)methyl)thiazolidine-2-carboxamide hydrochloride 
• 1041609-56-6 C₁₈H₂₃F₃N₄O₂S*ClH 
• 1041609-36-2 (3R)-3-amino-1-(2-(morpolin-4-carbonyl)thiazolidin-3-yl)-4-(2,4,5-trifluorophenyl)butan-1-one hydrochloride 
• 1041612-04-7 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 
• 1041609-58-8 N,N-dimethyl 3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxamide hydrochloride 
• 1041612-02-5 ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 1041611-88-4 2-(4-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-phenoxy)acetic acid 
• 1041611-87-3 ethyl 2-(4-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-phenoxy)acetate 
• 1041611-85-1 tert-butyl (2R)-4-(2-(benzylcarbamoyl)thiazolidin-3-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1041609-60-2 ethyl 2-(3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)acetate hydrochloride 
• 1041612-06-9 C₂₃H₃₀F₃N₃O₅S 

Relevant academic research and scientific papers

Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors

A series of β-aminoacyl containing thiazolidine derivatives was synthesized and evaluated for their ability to inhibit DPP-IV. Several thiazolidine derivatives with an acid moiety were found to be potent DPP-IV inhibitors. Among them, compound 2da is the most active in this series with an IC50 value of 1 nM, and it showed excellent selectivity over DPP-IV related enzymes including DPP-2, DPP-8, and DPP-9. Compound 2da is chemically and metabolically stable, and showed no CYP inhibition, hERG binding or cytotoxicity. Compound 2db, an ester prodrug of 2da, showed good in vivo DPP-IV inhibition after oral administration in rat and dog models.