1283688-40-3Relevant academic research and scientific papers
The resolution of trans-2,2-dichloro-3-methylcyclopropanecarboxylic acid via crystallization of its salts with (+)- and (-)-α-phenylethylamine, and the transformation of the resulting enantiomers into (R)- and (S)-dimethyl 2-methylsuccinates
Kovalenko, Vitaly N.,Kulinkovich, Oleg G.
, p. 26 - 30 (2011)
The resolution of trans-2,2-dichloro-3-methylcyclopropanecarboxylic acid trans-1 was achieved by crystallization of its salts with (+)- and (-)-α-phenylethylamine. The chiral acids were converted into methyl esters 9, which upon reaction with sodium methoxide in methanol underwent a three-carbon ring cleavage, leading to the corresponding mono-orthoester derivatives 10. Acidic hydrolysis then gave the known (R)- and (S)-dimethyl 2-methylsuccinates 12.
