1283747-24-9Relevant academic research and scientific papers
Scalable Electrochemical Transition-Metal-Free Dehydrogenative Cross-Coupling Amination Enabled Alkaloid Clausines Synthesis
Zhang, Pan,Li, Baoying,Niu, Liwei,Wang, Ling,Zhang, Guofeng,Jia, Xiaofei,Zhang, Guoying,Liu, Siyuan,Ma, Li,Gao, Wei,Qin, Dawei,Chen, Jianbin
, p. 2342 - 2347 (2020)
Reported herein is an environmentally benign electrochemical C?H bond dehydrogenative amination protocol for the construction of privileged carbazole moiety with broad generality. Preliminary mechanistic investigations implied a radical reaction pathway.
Synthesis of Carbazoles by a Merged Visible Light Photoredox and Palladium-Catalyzed Process
Choi, Sungkyu,Chatterjee, Tanmay,Choi, Won Joon,You, Youngmin,Cho, Eun Jin
, p. 4796 - 4802 (2015/08/18)
Carbazoles have attracted great interest in recent years for a variety of applications in organic and medicinal chemistry as well as in materials science. In this work, an efficient method for the synthesis of carbazoles through the intramolecular C-H bon
Intramolecular oxidative C-N bond formation for the synthesis of carbazoles: Comparison of reactivity between the copper-catalyzed and metal-free conditions
Cho, Seung Hwan,Yoon, Jungho,Chang, Sukbok
, p. 5996 - 6005 (2011/06/11)
New synthetic procedures for intramolecular oxidative C-N bond formation have been developed for the preparation of carbazoles starting from N-substituted amidobiphenyls under either Cu-catalyzed or metal-free conditions using hypervalent iodine(III) as an oxidant. Whereas iodobenzene diacetate or bis(trifluoroacetoxy)iodobenzene alone undergoes the reaction to provide carbazole products in moderate to low yields, combined use of copper(II) triflate and the iodine(III) species significantly improves the reaction efficiency, giving a more diverse range of products in good to excellent yields. On the basis of mechanistic studies including kinetic profile, isotope effects, and radical inhibition experiments, the copper species is proposed to catalytically activate the hypervalent iodine(III) oxidants. The synthetic utility of the present approach was nicely demonstrated in a direct synthesis of indolo[3,2-b]carbazole utilizing a double C-N bond formation.
