1283748-55-9Relevant academic research and scientific papers
Reaction of pyran-2-one with 5-amino-1H-pyrazoles: Synthesis and characterization of 5,7-dimethylpyrazolo[1,5-a] pyrimidines and their regioisomeric ethyl esters
Aggarwal, Ranjana,Rani, Chinu,Kumar, Rajiv
, p. 419 - 428 (2019/01/21)
In this work, the reaction of 4-hydroxy-6-methylpyran-2-one, a bifunctional compound, with various 5-amino-3/4-aryl-1H-pyrazoles in ethanol has been studied. While the reaction with 5-amino-3-aryl-1H-pyrazoles affords three products namely 5,7-dimethylpyrazolo[1,5-a]pyrimidines 3, ethyl 2-(7-methylpyrazolo [1,5-a]pyrimidin- 5-yl)acetates 4 and its regioisomer ethyl 2-(5-methylpyrazolo[1,5-a]pyrimidin-7- yl)acetates 5, 5-amino-4-aryl-1H-pyrazoles led to the formation of two products 5,7- dimethylpyrazolo[1,5-a] pyrimidines 7 and ethyl 2-(5-methylpyrazolo[1,5-a]pyrimidin- 7-yl)acetates 8. The products were characterized unambiguously by rigorous analysis of IR, NMR (1H and 13C) and mass spectrometry and a mechanism is proposed for their formation.
One-step reaction leading to new pyrazolo[1,5-a]pyrimidines by condensation of 2-pyrone with 5(3)-amino-3(5)-arylpyrazoles
Bassoude, Ibtissam,Berteina-Raboin, Sabine,Leger, Jean-Michel,Jarry, Christian,Essassi, El Mokhtar,Guillaumet, Gérald
experimental part, p. 2279 - 2286 (2011/04/22)
Condensation of 5(3)-amino-3(5)-arylpyrazoles with 4-hydroxy-6-methylpyran- 2-one leads to 5,7-dimethyl-2-arylpyrazolo[1,5-a]pyrimidines, 5-alkoxycarbonylmethyl-7-methyl-2-arylpyrazolo[1,5-a]pyrimidines and their isomeric 7-alkoxycarbonylmethyl-5-methyl-2
