128386-57-2 Usage
Uses
Used in Pharmaceutical Applications:
(R)-Perillyl alcohol is used as a therapeutic agent for its potential anti-cancer properties. In preclinical studies, it has shown promise in targeting cancer cells and inhibiting their growth, making it a subject of interest for the development of novel cancer treatments.
Used in Anti-Inflammatory Applications:
Due to its demonstrated anti-inflammatory properties, (R)-perillyl alcohol is used as an ingredient in pharmaceutical products aimed at reducing inflammation and alleviating pain associated with various conditions.
Used in Antimicrobial Applications:
(R)-Perillyl alcohol's antimicrobial activity makes it a potential candidate for use in the development of pharmaceutical and cosmetic products, where it can help combat harmful microorganisms and maintain a healthy microbial balance.
Used in Cosmetic Applications:
In the cosmetic industry, (R)-perillyl alcohol can be utilized for its anti-inflammatory and antimicrobial properties, contributing to the development of products that promote skin health and prevent the growth of harmful microorganisms on the skin.
Used in Flavor and Fragrance Industry:
Given its natural occurrence in plants like citrus fruits and mints, (R)-perillyl alcohol can be used as a component in the flavor and fragrance industry to add unique scents and flavors to various products.
Check Digit Verification of cas no
The CAS Registry Mumber 128386-57-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,3,8 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 128386-57:
(8*1)+(7*2)+(6*8)+(5*3)+(4*8)+(3*6)+(2*5)+(1*7)=152
152 % 10 = 2
So 128386-57-2 is a valid CAS Registry Number.
128386-57-2Relevant academic research and scientific papers
Synthesis of [15,15,15-2H3]-Dihydroartemisinic Acid and Isotope Studies Support a Mixed Mechanism in the Endoperoxide Formation to Artemisinin
Arman, Hadi D.,Varela, Kaitlyn,Yoshimoto, Francis K.
supporting information, p. 1967 - 1984 (2021/07/19)
Artemisinin is the plant natural product used to treat malaria. The endoperoxide bridge of artemisinin confers its antiparasitic properties. Dihydroartemisinic acid is the biosynthetic precursor of artemisinin that was previously shown to nonenzymatically undergo endoperoxide formation to yield artemisinin. This report discloses the synthesis of [15,15,15-2H3]-dihydroartemisinic acid and its use to determine the mechanism of endoperoxide formation. Several new observations were made: (i) Ultraviolet-C (UV-C) radiation initially accelerates artemisinin formation and subsequently promotes homolytic cleavage of the O-O bond and rearrangement of artemisinin to a different product, and (ii) dideuterated and trideuterated dihydroartemisinic acid isotopologues at C3 and C15 converted to artemisinin at a slower rate compared to nondeuterated dihydroartemisinic acid, revealing a kinetic isotope effect in the initial ene reaction toward endoperoxide formation (kH/kD～ 2-3). (iii) The rate of conversion from dihydroartemisinic acid to artemisinin increased with the amount of dihydroartemisinic acid, suggesting an intermolecular interaction to promote endoperoxide formation, and (iv)18O2-labeling showed incorporation of three and four oxygen atoms from molecular oxygen into the endoperoxide bridge of artemisinin. These results reveal new insights toward understanding the mechanism of endoperoxide formation in artemisinin biosynthesis.
