1283929-07-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(1-Hydroxybutyl)-6-MethoxynaphthaleneH831210 is used as an intermediate chemical in the synthesis of 2-Butyl-6-methoxynaphthalene (B693280) for the pharmaceutical industry. This application is essential because B693280 is an impurity associated with Nabumetone (N200500), a nonsteroidal anti-inflammatory drug (NSAID) used for treating various pain and inflammation conditions.
The role of 2-(1-Hydroxybutyl)-6-MethoxynaphthaleneH831210 in the pharmaceutical industry is to facilitate the production of Nabumetone by aiding in the synthesis of its related impurity, B693280. This process is vital for maintaining the quality, safety, and efficacy of Nabumetone as a medication.

Upstream product

• 3453-33-6 6-methoxynaphthalene-2-carbaldehyde 
• 106-94-5 propyl bromide 

Relevant academic research and scientific papers

Fluorescence-Based Kinetic Assay for High-Throughput Discovery and Engineering of Stereoselective ω-Transaminases

ω-Transaminases are a valuable class of enzymes for the production of chiral amines with either (R)- or (S)-configuration in high optical purity and 100% yield by the biocatalytic reductive amination of prochiral ketones. A versatile new assay was developed to quantify ω-transaminase activity for the kinetic characterization and enantioselectivity typing of novel or engineered enzymes based on the conversion of 1-(6-methoxynaphth-2-yl)alkylamines. The associated release of the acetonaphthone product can be monitored by the development of its bright fluorescence at 450 nm with very high sensitivity and selectivity. The assay principle can be used to quantify ω-transaminase catalysis over a very broad range of enzyme activity. Because of its simplicity and low substrate consumption in microtiter plate format the assay seems suitable for liquid screening campaigns with large library sizes in the directed evolution of optimized transaminases. For assay substrates that incorporate structural variations, an efficient modular synthetic route was developed. This includes racemate resolution by lipase-catalyzed transacylation to furnish enantiomerically pure (R)- and (S)-configured amines. The latter are instrumental for the rapid enantioselectivity typing of ω-transaminases. This method was used to characterize two novel (S)-selective taurine-pyruvate transaminases of the subtype 6a from thermophilic Geobacillus thermodenitrificans and G. thermoleovorans.