128397-18-2Relevant academic research and scientific papers
Selective Synthesis of Unsymmetrical Aliphatic Acyloins through Oxidation of Iridium Enolates
Sanz-Marco, Amparo,Martinez-Erro, Samuel,Martín-Matute, Belén
supporting information, p. 11564 - 11567 (2018/07/31)
The first method to access unsymmetrical aliphatic acyloins is presented. The method relies on a fast 1,3-hydride shift mediated by an IrIII complex in allylic alcohols followed by oxidation with TEMPO+. The direct conversion of allylic alcohols into acyloins is achieved in a one-pot procedure. Further functionalization of the Cα′ of the α-amino-oxylated ketone products gives access to highly functionalized unsymmetrical aliphatic ketones, which further highlights the utility of this transformation.
Thieme Chemistry Journal awardees - Where are they now? Intermolecular cross-acyloin reactions by fluoride-promoted additions of O-silyl thiazolium carbinols
Mathies, Alex K.,Mattson, Anita E.,Scheidt, Karl A.
experimental part, p. 377 - 383 (2009/10/01)
The addition of acyl anion equivalents to aliphatic aldehydes (crossed-acyloin reaction) has been developed. Cesium fluoride with isopropanol as solvent promotes the addition of O-silyl thiazolium carbinols to various aliphatic aldehydes in moderate to go
