128404-91-1

Upstream product

• 90-59-5 3,5-Dibromosalicylaldehyde 
• 61636-28-0 3-(2-amino-1,3-thiazol-4-yl)coumarin 

Downstream Products

• 90-59-5 3,5-Dibromosalicylaldehyde 
• 87503-74-0 2-chloro-N-[4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl]acetamide 
• 848903-51-5 3-[2-(3,5-dibromo-2-hydroxy-benzylamino)-thiazol-4-yl]-chromen-2-one 
• 128404-98-8 2-(2-hydroxy-3,5-dibromophenyl)-3-(4-(2-oxo-2H-1-benzopyran-3-yl)-2-thiazolyl)-4-thiazolidinone 

Relevant academic research and scientific papers

Synthesis and evaluation of anticancer and antiviral activity of some 2-aryl-3-(4-(2H-1-benzopyran-2-one-3-yl)-2-thiazolyl)-5-methyl-4-thiazolidinones

2-Aryl-3-(4-(2H-1-benzopyran-2-one-3-yl)-2-thiazolyl)-5-methyl-4- thiazolidinones (3), have been prepared by the reaction of Schiff's bases (2) with 2-mercaptopropionic acid. The Schiffs bases in turn are obtained by the reaction of various aldehydes with 3-(2-amino-4-thiazolyl)coumarins. The compounds 3 have been evaluated for their anticancer and antiviral activity.

Facile synthesis of some new 3-2-(1,3-benzoxazin-3-yl)-4-thiazolyl coumarins

3-(2-Substituted benzalimino-4-thiozolyl)-coumarins (1) on reduction with NaBH4 resulted in the formation of corresponding 3-(2-o-hydroxy benzyl hydrazino-4-thiazolyl)coumarins (2). These on condensation with formaldehyde gave the cycloproducts

REACTION OF MERCAPTOACETIC ACID AND CHLOROACETYL CHLORIDE WITH BENZALAMINO THIAZOLYL COUMARINS

2-Aryl-3--4-thiazolidinones (III), have been synthesized by the reaction of Schiff's bases (II) derived from 3-(2-amino-4-thiazolyl)-2H-1-benzopyran-2-ones (I) with mercaptoacetic acid.The Schiff's bases on reaction with chloroacetyl chloride in the presence of triethylamine in dioxane gave chloroacetamido derivative (IV) instead of expected compound V.