128407-56-7Relevant academic research and scientific papers
N-Heterocyclic Carbene Acyl Anion Organocatalysis by Ball-Milling
Nicholson, William I.,Seastram, Alex C.,Iqbal, Saqib A.,Reed-Berendt, Benjamin G.,Morrill, Louis C.,Browne, Duncan L.
, p. 131 - 135 (2019/12/11)
The ability to conduct N-heterocyclic carbene-catalysed acyl anion chemistry under ball-milling conditions is reported for the first time. This process has been exemplified through applications to intermolecular-benzoin, intramolecular-benzoin, intermolecular-Stetter and intramolecular-Stetter reactions including asymmetric examples and demonstrates that this mode of mechanistically complex organocatalytic reaction can operate under solvent-minimised conditions.
Design, synthesis and anti-mycobacterial activity of 1,2,3,5- tetrasubstituted pyrrolyl-N-acetic acid derivatives
Pagadala, Lakshmi Reddy,Mukkara, Lakshmi Devi,Singireddi, Satyanarayana,Singh, Ashita,Thummaluru, Veera Reddy,Jagarlamudi, Padma Sridevi,Guttala, Raja Sekhar,Perumal, Yogeeswari,Dharmarajan, Sriram,Upadhyayula, Suryanarayana Murty,Ummanni, Ramesh,Basireddy, Venkata Subba Reddy,Ravirala, Narender
, p. 118 - 126 (2014/07/22)
A novel synthesis of highly substituted pyrrole-N-acetic derivatives is described through the coupling of 1,4-diketones with amino acids following Paal-Knorr's approach. These pyrrole-N-acetic acid derivatives are found to exhibit potent anti-mycobacterial activity against Mycobacterium smegmatis and Mycobacterium tuberculosis strain H37Rv. In particular, 5n, 5q & 5r are found to display excellent anti-mycobacterial activity against M. tuberculosis strain H37Rv with MIC values in the range of 2.97 μM. Conversely, these compounds showed low cytotoxicity (selectivity index: >16.83) against HEK-293T cell line.
An efficient synthesis of 2-aryl-1,4-diketones via hydroacylation of enones
Lakshmi Reddy,Praveen Kumar,Satyanarayana,Narender,Subba Reddy
supporting information; experimental part, p. 1546 - 1549 (2012/04/10)
An improved method has been developed for the hydroacylation of enones with aldehydes employing bis-5-(2-hydroxyethyl)-1,3-thiazolium bromide/Et 3N system to afford the corresponding 1,4-diketones in good yields. This method is effective for the preparation of 1,4-diketones from both aromatic and aliphatic aldehydes.
Samarium-promoted michael addition between aroyl chlorides and chalcones
Liu, Yongjun,Li, Yuanying,Qi, Yan,Wan, Jun
experimental part, p. 4188 - 4192 (2011/02/25)
A novel Michael addition type reaction between aroyl chlorides and chalcones was realized in the presence of samarium metal when N,N-dimethylformamide was used as a solvent. A variety of 1,4-diketones were thereby synthesized in moderate to good yields. T
Reactions of 2-(Dialkylamino)arylacetonitriles with Acetylenes Under Basic Conditions. A Simple Synthesis of Substituted Mono and Diketones
Zdrojewski, T.,Jonczyk, A.
, p. 224 - 233 (2007/10/02)
2-(Dialkylamino)arylacetonitriles 1 react with acetylenes 2a,b in dimethyl sulfoxide, powdered sodium hydroxide and triethylbenzylammonium chloride as a catalyst to give 3 and/or 4.The latter are formed via addition of anion 8 to immonium salt 9.The type of product formed depends on the basicity of amino moiety in 3.Furthermore, compound 1 adds to C-1 of acetylene 2c affording the vinyl derivatives 15.The products 3,4,11 and 15 are hydrolyzed to give ketones 5-7,12 and 16, respectively.
