1284151-81-0Relevant articles and documents
Synthesis of saturated 1,4-benzodiazepines via Pd-catalyzed carboamination reactions.
Neukom, Joshua D.,Aquino, Alvin S.,Wolfe, John P.
, p. 2196 - 2199 (2011/06/25)
Chemical equations presented. A new synthesis of 1,4-benzodiazepines and 1,4-benzodiazepin-5-ones is reported. The Pd-catalyzed coupling of N-allyl-2-aminobenzylamine derivatives with aryl bromides affords the heterocyclic products in good yield, and substrates bearing allylic methyl groups are transformed to cis-2,3-disubstituted products with >20:1 dr.