1284199-22-9

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 355391-05-8 4-(cyclopropylmethoxy)benzoic acid 

Downstream Products

• 1190044-92-8 ethyl 6-{[4-(cyclopropylmethoxy)benzoyl]amino}-2-naphthoate 
• 1018856-62-6 4-(cyclopropylmethoxy)-N-(3-formyl-8-methylquinolin-7-yl)benzamide 
• 1190044-62-2 N-(3-amino-2-fluorophenyl)-4-(cyclopropylmethoxy)benzamide 
• 521073-44-9 4-(cyclopropylmethoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]benzamide 
• 1189119-64-9 N-(3-amino-2-methylphenyl)-4-(cyclopropylmethoxy)benzamide 
• 1431533-84-4 tert-butyl 4-((4-(cyclopropylmethoxy)benzoyl)amino)-3-hydroxypiperidine-1-carboxylate 
• 1431533-08-2 4-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide 
• 1443367-30-3 8-(4-(cyclopropylmethoxy)benzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 1373823-17-6 4-(cyclopropylmethoxy)-N-[8-methyl-3-(1-methyl-1-pyrrolidin-1-ylethyl)quinolin-7-yl]benzamide 
• 1373823-16-5 4-(cyclopropylmethoxy)-N-[3-(1-hydroxy-1-methylethyl)-8-methylquinolin-7-yl]benzamide 
• 1373823-15-4 methyl 7-{[4-(cyclopropylmethoxy)benzoyl]amino}-8-methylquinoline-3-carboxylate 
• 1373823-14-3 N-{3-[(1R)-1-{(2-aminoethyl)[(2-nitrophenyl)sulfonyl]-amino}ethyl]-8-methylquinolin-7-yl}-4-(cyclopropylmethoxy)-benzamide 
• 1373823-13-2 4-(cyclopropylmethoxy)-N-{8-methyl-3-[(1R)-1-{[(2-nitrophenyl)sulfonyl]amino}ethyl]quinolin-7-yl}benzamide 
• 1190044-49-5 N-{3-[(1R)-1-aminoethyl]-8-methylquinolin-7-yl}-4-(cyclopropylmethoxy)benzamide 

Relevant academic research and scientific papers

Synthesis of a stable triformylmethane synthon and its scalable application to 7-acylamino-3-formylquinoline syntheses

Novel 2-iminiomethylvinamidinium trihalides were isolated as stable crystals and found to be useful triformylmethane synthons with non-deliquescent nature in air. They were easier to manufacture, handle, and store than the known 2-iminiomethylvinamidinium

BICYCLIC COMPOUND

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

8-benzamidochromen-4-one-2-carboxylic acids: Potent and selective agonists for the orphan G protein-coupled receptor GPR35

8-Amido-chromen-4-one-2-carboxylic acid derivatives were identified as novel agonists at the G protein-coupled orphan receptor GPR35. They were characterized by a β-arrestin recruitment assay and optimized to obtain agonists with nanomolar potency for the

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3- aminomethylquinolines: Reducing human ether-a-go-go-related gene (hERG) associated liabilities

Recently, we discovered 3-aminomethylquinoline derivative 1, a selective, highly potent, centrally acting, and orally bioavailable human MCH receptor 1 (hMCHR1) antagonist, that inhibited food intake in F344 rats with diet-induced obesity (DIO). Subsequent investigation of 1 was discontinued because 1 showed potent hERG K+ channel inhibition in a patch-clamp study. To decrease hERG K+ channel inhibition, experiments with ligand-based drug designs based on 1 and a docking study were conducted. Replacement of the terminal p-fluorophenyl group with a cyclopropylmethoxy group, methyl group introduction on the benzylic carbon at the 3-position of the quinoline core, and employment of a [2-(acetylamino)ethyl]amino group as the amine portion eliminated hERG K+ channel inhibitory activity in a patch-clamp study, leading to the discovery of N-{3-[(1R)-1-{[2-(acetylamino)ethyl]amino} ethyl]-8-methylquinolin-7-yl}-4-(cyclopropylmethoxy)benzamide (R)-10h. The compound (R)-10h showed potent inhibitory activity against hMCHR1 and dose-dependently suppressed food intake in a 2-day study on DIO-F344 rats. Furthermore, practical chiral synthesis of (R)-10h was performed to determine the molecule's absolute configuration.

HETEROCYCLIC COMPOUND

The present invention provides to a compound having melanin-concentrating hormone receptor antagonistic action and low toxicity, and useful as a agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound re