128421-57-8

Basic information

• Product Name: 5-(4-Chloro-phenyl)-3-(2,4,6-trimethyl-phenyl)-isoxazole-4-carbonitrile
• CAS NO: 128421-57-8
• Molecular Weight: 322.794
• Mol File: 128421-57-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-Chloro-phenyl)-3-(2,4,6-trimethyl-phenyl)-isoxazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chloro-phenyl)-3-(2,4,6-trimethyl-phenyl)-isoxazole-4-carbonitrile(128421-57-8)
• EPA Substance Registry System: 5-(4-Chloro-phenyl)-3-(2,4,6-trimethyl-phenyl)-isoxazole-4-carbonitrile(128421-57-8)

Safety Data

• Hazardous Substances Data: 128421-57-8(Hazardous Substances Data)

Upstream product

• 17197-20-5 3-amino-3-(4-chlorophenyl)acrylonitrile 
• 2904-57-6 mesitylenecarbonitrile oxide 

Relevant articles and documents

A Kinetic Study of the 1,3-Cycloaddition of Benzonitrile Oxides to para-Substituted β-Aminocinnamonitriles

Stable arylnitrile oxides undergo 1,3-cycloaddition to β-aminocinnamonitriles at the CN or the C=C bond, which gives rise to 3,5-disubstituted 1,2,4-oxadiazoles or 3,5-diaryl-4-cyanoisoxazoles, respectively, by parallel reactions in different solvents.Overall kinetics were measured at temperatures in the range 50-90 deg C; product selectivities were determined by HPLC, rate coefficients for the parallel reactions were, thus, obtained.Rates were enhanced by increasing the solvent polarity.Hammett plots for substitution on the nitrile oxide benzene ring were V-shaped; those for substitution on the enaminonitrile benzene ring had negative ρ-values.