1284243-09-9Relevant articles and documents
Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
Shotwell, J. Brad,Baskaran, Subramanian,Chong, Pek,Creech, Katrina L.,Crosby, Renae M.,Dickson, Hamilton,Fang, Jing,Garrido, Dulce,Mathis, Amanda,Maung, Jack,Parks, Derek J.,Pouliot, Jeffrey J.,Price, Daniel J.,Rai, Roopa,Seal, John W.,Schmitz, Uli,Tai, Vincent W. F.,Thomson, Michael,Xie, Mi,Xiong, Zhiping Z.,Peat, Andrew J.
scheme or table, p. 565 - 569 (2012/09/11)
A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC50 10 nM), direct binding to purified NS4B protein (ICsub