1284243-18-0Relevant academic research and scientific papers
Imidazo[1,2-a]pyridines that directly interact with hepatitis C NS4B: Initial preclinical characterization
Shotwell, J. Brad,Baskaran, Subramanian,Chong, Pek,Creech, Katrina L.,Crosby, Renae M.,Dickson, Hamilton,Fang, Jing,Garrido, Dulce,Mathis, Amanda,Maung, Jack,Parks, Derek J.,Pouliot, Jeffrey J.,Price, Daniel J.,Rai, Roopa,Seal, John W.,Schmitz, Uli,Tai, Vincent W. F.,Thomson, Michael,Xie, Mi,Xiong, Zhiping Z.,Peat, Andrew J.
scheme or table, p. 565 - 569 (2012/09/11)
A series of imidazo[1,2-a]pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro inhibition of HCV replication (EC50 10 nM), direct binding to purified NS4B protein (ICsub
PIPERAZINYL ANTIVIRAL AGENTS
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, (2011/04/25)
Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
