1284244-71-8Relevant articles and documents
Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition
Madden, Michael M.,Muppidi, Avinash,Li, Zhenyu,Li, Xiaolong,Chen, Jiandong,Lin, Qing
, p. 1472 - 1475 (2011)
We report the first application of a photoinduced 1,3-dipolar cycloaddition reaction to 'staple' a peptide dual inhibitor of the p53-Mdm2/Mdmx interactions. A series of stapled peptide inhibitors were efficiently synthesized and showed excellent dual inhi