1284249-22-4

Usage

Uses

Used in Pharmaceutical Applications:
(trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride is used as a therapeutic agent for the treatment of various neurological disorders due to its potential neuroprotective and neuroregenerative properties.
Used in Research and Development:
In the research industry, (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride is used as a building block for the synthesis of other complex organic molecules, contributing to the development of novel compounds with diverse applications.
Used as a Reagent in Chemical Reactions:
(trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride serves as a reagent in various chemical reactions, facilitating the creation of new compounds and aiding in the advancement of chemical research.
Used in Laboratory Settings:
The hydrochloride salt form of (trans)-bicyclo[3.1.0]hex-3-ylamine makes it more readily available and easier to handle, making it a preferred choice for laboratory experiments and procedures.
Overall, (trans)-bicyclo[3.1.0]hex-3-ylamine hydrochloride plays a significant role in both the pharmaceutical and research industries due to its versatile properties and potential applications.

Upstream product

• 694-43-9 (1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol 
• 79531-79-6 trans-3-Amino-bicyclo<3,1,0>hexan 
• 1284249-21-3 2-[(trans)-bicyclo[3.1.0]hex-3-yl]-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

Hepatitis C replication inhibitors that target the viral NS4B protein

We describe the preclinical development and in vivo efficacy of a novel chemical series that inhibits hepatitis C virus replication via direct interaction with the viral nonstructural protein 4B (NS4B). Significant potency improvements were realized through isosteric modifications to our initial lead 1a. The temptation to improve antiviral activity while compromising physicochemical properties was tempered by the judicial use of ligand efficiency indices during lead optimization. In this manner, compound 1a was transformed into (+)-28a which possessed an improved antiviral profile with no increase in molecular weight and only a modest elevation in lipophilicity. Additionally, we employed a chimeric "humanized" mouse model of HCV infection to demonstrate for the first time that a small molecule with high in vitro affinity for NS4B can inhibit viral replication in vivo. This successful proof-of-concept study suggests that drugs targeting NS4B may represent a viable treatment option for curing HCV infection.

BENZIMIDAZOLE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and/or Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).