128425-83-2Relevant academic research and scientific papers
Some Isoindolo-fused Heterocyclic Systems by Cyclodehydration of N-Arylalkyl-3-hydroxyphthalimidines
Hitchings, Gregory J.,Helliwell, Madeleine,Vernon, John M.
, p. 83 - 87 (2007/10/02)
α-Hydroxy-lactams formed by reduction or Grignard addition to appropriately N-substituted phthalimides (1a-d) undergo acid-catalysed cyclodehydration to derivatives of the isoindolo-fused heterocyclic systems (6)-(10).Ring closures to the naphthalene 2- or 8-position are observed to occur with N-1-naphthylalkyl substituents, the latter proved by an X-ray crystal structure determination of 13b-phenyl-7H-benzisoindoloisoquinolin-9(13H)-one (9b).
