1284312-35-1

Basic information

• Product Name: 3-phenyl-5-(N-methyl-3'-indolyl)-1,2,4-triazole
• Synonyms: 3-phenyl-5-(N-methyl-3'-indolyl)-1,2,4-triazole
• CAS NO: 1284312-35-1
• Molecular Weight: 274.325
• Mol File: 1284312-35-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-phenyl-5-(N-methyl-3'-indolyl)-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-5-(N-methyl-3'-indolyl)-1,2,4-triazole(1284312-35-1)
• EPA Substance Registry System: 3-phenyl-5-(N-methyl-3'-indolyl)-1,2,4-triazole(1284312-35-1)

Safety Data

• Hazardous Substances Data: 1284312-35-1(Hazardous Substances Data)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 24662-37-1 1-methyl-1H-indole-3-carbonitrile 
• 19012-03-4 N-methyl-3-formylindole 
• 487-89-8 Indole-3-carboxaldehyde 
• 120-72-9 indole 

Relevant articles and documents

Synthesis of Novel Indolyl-1,2,4-triazoles as Potent and Selective Anticancer Agents

A diverse series of 22 indolyl-1,2,4-triazole congeners (6 and 7) have been synthesized from the reaction of indole-3-carbonitrile (4) or (5) with appropriate acid hydrazides in the presence of potassium carbonate. Synthesized compounds were evaluated for their cytotoxicity against six human cancer cell lines, and some of the compounds displayed promising activity. In particular, 3-(3',4',5'-trimethoxyphenyl)-5-(N-methyl-3'-indolyl)-1,2,4-triazole (7i) and 3-(4'-piperidinyl)-5-(N-methyl-3'-indolyl)-1,2,4-triazole (7n) were the most promising and broadly active compounds against the tested cell lines. It was interesting to note that the trimethoxyphenyl analog 7i showed twofold selective cytotoxicity against PaCa2 cell line (IC50 0.8μm), whereas piperidinyl analog 7n was found to be selectively cytotoxic against MCF7 cell line (IC50 1.6μm). Notably, the 4-fluorophenyl derivative 7c exhibited selective cytotoxicity against PC3 cell line (IC50 4μm). The structure-activity relationship study revealed that substituents including 3,4,5-trimethoxyphenyl, 3,4-dimethoxyphenyl, 4-benzyloxy-3-methoxyphenyl, 4-piperidinyl, 4-fluorophenyl and N-methylindole are beneficial for the activity of indolyl-1,2,4-triazoles (6 and 7).