128434-80-0 Usage
Synthetic analog of retinal
10,20-methanoretinal is a synthetic molecule that is similar in structure to the natural retinal found in the eye.
Developed for optogenetics and vision restoration therapies
10,20-methanoretinal has been specifically designed for use in optogenetics, a technique that uses light to control the activity of cells, and in vision restoration therapies, which aim to restore vision in individuals with degenerative eye conditions.
Light-sensitive molecule
10,20-methanoretinal is sensitive to light and can absorb photons, which can trigger a response in the cells in which it is incorporated.
Improved stability and functionality
10,20-methanoretinal has been engineered to have improved stability and functionality compared to natural retinal, making it a more effective and reliable molecule for use in optogenetic applications.
Potential use in research and development
In addition to its potential use in vision restoration, 10,20-methanoretinal also has the potential to be used in research and development of novel optogenetic tools for studying neural circuits and brain function.
Check Digit Verification of cas no
The CAS Registry Mumber 128434-80-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,4,3 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128434-80:
(8*1)+(7*2)+(6*8)+(5*4)+(4*3)+(3*4)+(2*8)+(1*0)=130
130 % 10 = 0
So 128434-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H28O/c1-16(19-10-8-18(9-11-19)13-15-22)7-12-20-17(2)6-5-14-21(20,3)4/h7-8,10,12-13,15H,5-6,9,11,14H2,1-4H3/b12-7+,18-13-,19-16-
128434-80-0Relevant academic research and scientific papers
Synthesis and spectroscopic characterization of the doubly locked 9E,11Z retinal model systems 7E,13E-11,19-10,29-dimethanoretinal and its 13Z isomer
Groesbeek, M.,Robijn, G. W.,Lugtenburg, J.
, p. 92 - 98 (2007/10/02)
7E,13E-11,19-10,20-dimethanoretinal (1) and its 13Z isomer 2 were prepared from β-ionone, using the novel synthon 2-(diethoxyphosphinyl)-5,5-dimethoxyhexanenitrile.This synthon was also used to prepare 7E,9E,13E-10,20-methanoretinal (3) and its 13Z isomer 4 in high yield, starting from β-ionone.Spectroscopic analysis (mass, 1H and 13C NMR and UV/Vis) of these compounds is discussed.The introduction of the methano bridges leads to minimal steric and electronic changes.The photostationary state reached from 1 and 2 has the 13Z form 2 as the main constituent.This is one of the very few with a Z form as the main constituent of the photostationary state. 1 and 2 are very sensitive to acid-catalyzed isomerization of the 13-C=14-C double bond.The presence of the 11,19-methano bridge is responsible for this efficient Z-E isomerization.
