128435-06-3Relevant academic research and scientific papers
Oligonucleotide analogs containing sulfur linkages
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, (2008/06/13)
Analogs of DNA containing sulfides, sulfoxides, and sulfones as linking groups between subunits capable of forming bonds with natural oligonucleotides are described. The analogs are lipophilic, stable to chemical degradation under a wide range of conditions and stable to enzymatic degradation in vivo.
Building Blocks for Oligonucleotide Analogues with Dimethylene Sulfide, Sulfoxide, and Sulfone Groups Replacing Phosphodiester Linkages
Huang, Zhen,Schneider, K. Christian,Benner, Steven A.
, p. 3869 - 3882 (2007/10/02)
Two routes are presented for the synthesis of 3',5'-bishomodeoxyribonucleosides, building blocks needed to synthesize oligodeoxynucleotide analogues where the OPO2O groups are replaced by CH2SCH2, CH2SOCH2, and CH2SO2CH2 units.Two of these have been coupl
