128438-01-7

Usage

Uses

Used in Pharmaceutical Research:
(Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid is used as a potential candidate for pharmaceutical research due to its unique chemical structure and properties. Its trityl group, aminothiazole ring, and acetic acid group connected by an oxyimino linker may contribute to its potential biological activities, making it a promising compound for further investigation in drug development.
Used in Biochemistry:
(Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid is used as a compound of interest in the field of biochemistry, where its chemical properties and interactions with biological systems can be studied. This may lead to a better understanding of its potential functions and applications in various biological processes.
Note: As the provided materials do not specify the exact applications and industries for (Z)-2-(2-Aminothiazole-4-yl-)-2-trityloxyimino acetic acid, the uses listed above are based on the general potential of the compound in pharmaceutical research and biochemistry. Further research and studies are needed to determine its specific applications and safety profiles.

InChI:InChI=1/C24H19N3O3S/c25-23-26-20(16-31-23)21(22(28)29)27-30-24(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-16H,(H2,25,26)(H,28,29)/b27-21-

Upstream product

• 76-83-5 trityl chloride 
• 64485-82-1 (Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate 
• 128438-00-6 ethyl (2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetate 
• 76-84-6 triphenylmethyl alcohol 

Downstream Products

• 163009-35-6 7β-acylcephem 
• 68786-47-0 (Z)-2-(trityloxyimino)-2-(2-tritylamino-4-thiazolyl)acetic acid 
• 288379-92-0 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(Z)-2-(3-pyridyl)vinylthio]-3-cephem-4-carboxylate 
• 288379-65-7 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(E)-2-(3-pyridyl)thiovinyl]-3-cephem-4-carboxylic acid 
• 288380-03-0 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(E)-2-(4-pyridyl)thiovinyl]-3-cephem-4-carboxylic acid 
• 143183-03-3 S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate 
• 189449-52-3 (Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid 
• 288379-89-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-(4-pyridylthio)-3-cephem-4-carboxylate 
• 288380-05-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(4-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 
• 163009-34-5 diphenylmethyl 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[2-(4-pyridyl)ethylthio]-3-cephem-4-carboxylate 
• 288379-94-2 diphenylmethyl 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(trityloxyimino)acetamido]-3-[(3-pyridyl)thiomethylthio]-3-cephem-4-carboxylate 
• 200814-98-8 (Z)-(2-aminothiazol-4-yl)triphenylmethyloxyimino acetic acid diethoxythiophosphoryl ester 
• 163009-37-8 diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(1-tritylpyrazol-4-yl)methylthio]-3-cephem-4-carboxylate 
• 220779-81-7 (6R,7R)-3-[(Z)-2-(3-Methoxy-isoxazol-5-yl)-vinyl]-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Relevant academic research and scientific papers

PROCESS FOR PREPARING 2-AMINOTHIAZOL-4-YL-ACETIC ACID DERIVATES

The invention provides a process for preparing a (2-aminothiazol-4-yl)-triarylmethyloxy- iminoacetic acid of the formula (I) or an ester thereof of the formula (II) wherein R1, R2 and R3 independently are optionally substi

Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria

The discovery of RWJ-54428 (MC-02,479), a new cephalosporin displaying promising activity against sensitive and resistant Gram-positive bacteria, is described. Progressive structural modification from the previously reported 3-phenylthiocephem MC-02,331 afforded an overall increase in potency against MRSA while retaining other key properties such as acceptable solubility and serum binding. Evaluation of the in vitro potency and in vivo efficacy of a series of closely related compounds resulted in selection of RWJ-54428 (MC-02,479) for further studies.

Synthesis of HR 916 K: An efficient route to the pure diastereomers of the 1-(pivaloyloxy)ethyl esters of cephalosporins

HR 916 K (5), the 1-(S)-(pivaloyloxy)ethyl prodrug ester of the cephalosporin cefdaloxime, exhibits a significantly higher oral bioavailability than the 1-(R) diastereomer HR 916 J. An efficient synthesis of HR 916 K was developed. The separation of the diastereomers was achieved by precipitation of the 1-(R)-hydrochloride 9 followed by crystallization of the 1-(S)-amine 10 (de > 96%). The 1-(R) diastereomer 9 was recycled by acidic saponification or enzymatic cleavage to AMCA (7). The amine 10 was acylated with mercaptobenzothiazole thioesters or mixed anhydrides, prepared from carboxylic acids 13 and 14, in almost quantitative yield. Deprotection of the oxime and formation of the tosylate proceeded in one step. Using thioester 18, we obtained HR 916 K (5) from AMCA (7) in 42% yield. VCH Verlagsgesellschaft mbH, 1996.

Process for the preparation of cephem prodrug esters

The invention relates to a process for the preparation of cephem prodrug esters of the formula: STR1 in which R1 is C1 -C5 -alkanoyloxy-C1 -C3 -alkyl or C1 -C5 -alkoxycarbonyloxy

Process for cephem prodrug esters

A process for the selective formation of oximino o-protected derivatives of lower alkyl 2-(2-aminothiazol-4-yl)-2-oximinoacetates, and their use in the acylation of 7-amino-cephalosporin compounds is disclosed.