128452-48-2

Basic information

• Product Name: 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI)
• Synonyms: 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI)
• CAS NO: 128452-48-2
• Molecular Formula: C₃H₂ClN₃O₂
• Molecular Weight: 147.51988
• Product Categories: OXIME
• Mol File: 128452-48-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI)(128452-48-2)
• EPA Substance Registry System: 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI)(128452-48-2)

Safety Data

• Hazardous Substances Data: 128452-48-2(Hazardous Substances Data)

Usage

General Description

1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI) is a chemical compound with the molecular formula C3H3ClN2O2. It is a derivative of 1,2,4-oxadiazole and is primarily used in the synthesis of pharmaceuticals and other organic compounds. 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI) has the potential to act as a reagent in various organic reactions, particularly in the formation of carbon-nitrogen and carbon-oxygen bonds. It is also known to exhibit biological activity, making it a valuable tool in medicinal chemistry research. However, as with any chemical compound, proper handling and safety precautions should be taken when working with 1,2,4-Oxadiazole-3-carboximidoylchloride,N-hydroxy-(9CI) to minimize the risk of exposure and ensure safe laboratory practices.

Upstream product

• 2580-79-2 diaminoglyoxime 
• 122-51-0 orthoformic acid triethyl ester 
• 39512-81-7 1,2,4-oxadiazole-3-carboxamidoxime 

Downstream Products

• 147594-86-3 1,2,4-oxadiazole-3-carboxylic acid phenylamidrazone 

Relevant articles and documents

Synthesis and Characterization of the Potential Melt-Castable Explosive 3-(1,2,4-Oxadiazolyl)-5-Nitratomethyl Isoxazole

The synthesis of 3-(1,2,4-oxadiazolyl)-5-nitratomethyl isoxazole (C6H4N4O5), its physical properties, and its theoretical performances are described. This energetic material was found to have a melting point range of 76.6–79.2 °C, and a thermal onset decomposition temperature of 184.5 °C. These thermal features put this material into the standalone melt-castable explosive class. The material was found to have TNT performance, and was found to be insensitive to impact, friction, and electrostatic discharge, despite having a nitric ester functionality. A critical reaction in making this molecule was the desymmetrization of diaminoglyoxime. The optimization of this transformation is described. Previous reports of this desymmetrization were found to be inaccurate, as the desymmetrization reaction produces a co-crystal of mono- and bi-1,2,4-oxadiazole products.

SYNTHESIS OF THE AMIDES AND ACID HALIDES OF 1,2,4-OXADIAZOLE-3-CARBOHYDROXAMIC ACID

The reaction of diaminoglyoxime with carboxylic acid derivatives gave the amidoximes of 1,2,4-oxadiazole-3-carboxylic acid.It has been found that in the nitrozation of the obtained amidoximes in a solution of hydrochloric or hydrobromic acid the corresponding halooximes are formed.