128483-30-7

Upstream product

• 128483-26-1 2-Mercapto-4-p-chlorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline 
• 79-11-8 chloroacetic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 3028-02-2 N-benzothiazol-2-yl-2-chloroacetamide 
• 587-65-5 N-chloroacetyl-aniline 
• 49545-70-2 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one 

Downstream Products

• 1628075-47-7 7-(4-chlorophenyl)-10-((5-methoxy-1H-indol-3-yl)methylene)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 1628075-48-8 10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 1628075-46-6 7-(4-chlorophenyl)-10-((2-methyl-1H-indol-3-yl)methylene)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 368846-07-5 10-((1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one 
• 128483-34-1 2-(p-chlorophenylmethylene)-5-p-chlorophenyl-5H-2,3,6,7-tetrahydrobenzothiazolo<2,3-b>quinazoline-3-one 

Relevant academic research and scientific papers

Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound 6c confirmed the structure of all the reaction products.

Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: Synthesis, characterization and evaluation of anticancer and antimicrobial activities

A series of novel 10-((1H-indol-3-yl)methylene)-7-aryl-7,10-dihydro-5H- benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-ones (8a-t) have been synthesized in good yields by the reaction of benzo[h]quinazoline-2(1H)-thiones (4a-f) with 2-chloro-N-phenylacetamide (5) followed by Knoevenagel condensation with various indole-3-carbaldehydes (7a-d) under conventional method. All the synthesized compounds were characterized by spectral studies and screened for their in vitro anticancer and antimicrobial activities. Compound 8c has exhibited excellent activity against MCF-7 (breast cancer cell line) than the standard drug Doxorubicin. Compound 8d against both the cancer cell lines, 8q against MCF-7 and 8c, 8h against HepG2 have also shown good activity. Remaining compounds have shown moderate activity against both the cell lines. Antimicrobial activity revealed that, the compound 8q and 8t against Staphylococcus aureus and 8i, 8k, 8l, 8q & 8t against Klebsiella pneumoniae have shown equipotent activity on comparing with the standard drug Streptomycin. Remaining compounds have shown significant antibacterial and comparable antifungal activities against all the tested microorganisms.

Heterocyclic systems containing bridgehead nitrogen atom: Part LXXV - Syntheses of thiazolobenzoquinazolines and thiazinobenzoquinazolines

2-Arylidenetetralin-1-ones (1a-c) on condensation with thiourea give 4-aryl-3,4,5,6-tetrahydrobenzoquinazoline-2(1H)-thiones (2a-c) which on reaction with chloroacetic acids, α- and β-halopropionic acids afford 5-aryl-2,3,6,7-tetrahydro-3-oxo-5H-thiazo

SYNTHESIS AND REACTIONS OF 2-MERCAPTO-4-ARYL 4H-1,2,3,4,5,6-HEXAHYDRO-BENZOQUINAZOLINES

2-Mercapto-4-aryl-4H-1,2,3,4,5,6-hexahydrobenzoquinazolines (2), have been synthesized.Compounds 2 reacted with chloroacetic acid, 2-bromopropanoic acid or 3-bromopropanoic acid in the presence of fused sodium acetate and acetic anhydride to give 5-ary