128483-52-3

Upstream product

• 23173-02-6 18-hydroxygardnerine 
• 23173-00-4 18-hydroxygardnutine 

Downstream Products

• 128483-53-4 Acetic acid (2R,6S)-3-[2-acetoxy-eth-(E)-ylidene]-10-hydroxy-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-13-ylmethyl ester 
• 1358-76-5 koumine 
• 128466-33-1 Acetic acid (2R,6S)-3-[2-acetoxy-eth-(E)-ylidene]-12-(toluene-4-sulfonyl)-10-trifluoromethanesulfonyloxy-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-13-ylmethyl ester 
• 128483-54-5 Trifluoro-methanesulfonic acid (2R,6S)-3-[2-hydroxy-eth-(E)-ylidene]-13-hydroxymethyl-12-(toluene-4-sulfonyl)-1,3,4,7,12,12b-hexahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-10-yl ester 
• 128466-34-2 2-[(2R,6S)-13-Hydroxymethyl-12-(toluene-4-sulfonyl)-1,7,12,12b-tetrahydro-2H,6H-2,6-methano-indolo[2,3-a]quinolizin-(3E)-ylidene]-ethanol 

Relevant academic research and scientific papers

BIOMIMETIC SYNTHESIS OF KOUMINE BY THE PALLADIUM-CATALYZED INTRAMOLECULAR COUPLING REACTION OF 18-HYDROXYTABERPSYCHINE (18-HYDROXYANHYDROVOBASINEDIOL)

A principal Gelsemium alkaloid, koumine (1) was synthesized from 18-hydroxygardnutine (3) via the demethoxylation from the indole ring and the palladium-catalyzed cyclization between C7 and C20 of the hypothetical biogenetic intermediate, 18-hydroxytaberpsychine (2).