128494-83-7

Upstream product

• 128487-85-4 (2RS, 3SR)-5-<2-(dimethylamino)ethyl>-2,3-dihydro-3-hydroxy-2-hydroxymethyl-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 108-24-7 acetic anhydride 
• 93080-36-5 3-acetoxy-5-<2-(dimethylamino)ethyl>-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 97801-78-0 3-acetoxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 27068-88-8 3c-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 

Relevant academic research and scientific papers

SYNTHESIS OF 2-SUBSTITUTED DERIVATIVES OF DILTIAZEM

Titled compounds, 2a,b,c,d and e, were efficiently synthesized from 3-acetoxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (4) through alkylation at the C2- position followed by stereoselective reduction of the C3- carbonyl group.