128496-05-9

Basic information

• Product Name: 1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine
• Synonyms: 1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine
• CAS NO: 128496-05-9
• Molecular Weight: 471.417
• Mol File: 128496-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine(128496-05-9)
• EPA Substance Registry System: 1-(3,5-O-dibenzoyl-2-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine(128496-05-9)

Safety Data

• Hazardous Substances Data: 128496-05-9(Hazardous Substances Data)

Upstream product

• 2022-85-7 Flucytosine 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 

Downstream Products

• 128496-07-1 1-<5-O-benzoyl-2-deoxy-fluoro-3-O--β-D-arabinofuranosyl>)-5-fluorocytosine 
• 128496-08-2 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-5-fluorocytosine 
• 128496-09-3 1-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)-5-fluorocytosine 
• 128496-06-0 1-(5-O-benzoyl-2-deoxy-fluoro-β-D-arabinofuranosyl)-5-fluorocytosine 

Relevant articles and documents

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)

A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluaed against human immunodeficiency virus (HIV-1) in a human lymphoblastoid cell line. Among these compounds, 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12), 2',3'-didehydro-2',3'-dideoxy-2'-fluorocytidine (35), 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)cytosine (41), and 3'-deoxy-2',3'-didehydro-2'-fluorothymidine (45) were found to have significant antiviral activity, with IC50 values of 0.65, 10, 10, and 100 μM, respectively. The structure-activity relationships are discussed.