128496-20-8 Usage
Uses
Used in Antiviral Applications:
DDFC is used as an antiviral agent for its ability to inhibit the replication of several viruses, such as herpes simplex virus, hepatitis B virus, and human immunodeficiency virus (HIV). Its mechanism of action involves interference with viral DNA or RNA synthesis, which makes it an attractive candidate for the treatment of viral infections.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DDFC is used as a key component in the development of new antiviral drugs. Its antiviral activity and potential to inhibit the replication of various viruses make it a valuable asset in the fight against viral diseases.
Used in Research and Development:
DDFC is also utilized in research and development for the study of its antiviral properties and potential applications in the treatment of viral infections. This includes exploring its mechanism of action, as well as investigating its effectiveness in combination with other antiviral agents or therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 128496-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,4,9 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128496-20:
(8*1)+(7*2)+(6*8)+(5*4)+(4*9)+(3*6)+(2*2)+(1*0)=148
148 % 10 = 8
So 128496-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H11F2N3O3/c10-6-4(3-15)17-8(7(6)11)14-2-1-5(12)13-9(14)16/h1-2,4,6-8,15H,3H2,(H2,12,13,16)/t4-,6-,7+,8-/m1/s1
128496-20-8Relevant academic research and scientific papers
Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)
Martin,Bushnell,Duncan,Dunsdon,Hall,Machin,Merrett,Parkes,Roberts,Thomas,Galpin,Kinchington
, p. 2137 - 2145 (2007/10/02)
A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluaed against human immunodeficiency virus (HIV-1) in a human lymphoblastoid cell line. Among these compounds, 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12), 2',3'-didehydro-2',3'-dideoxy-2'-fluorocytidine (35), 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)cytosine (41), and 3'-deoxy-2',3'-didehydro-2'-fluorothymidine (45) were found to have significant antiviral activity, with IC50 values of 0.65, 10, 10, and 100 μM, respectively. The structure-activity relationships are discussed.
