128524-26-5

Basic information

• Product Name: 3'-DEOXYTHYMIDINE-5'-O-TRIPHOSPHATE/2',3'-DIDEOXYTHYMIDINE-5'-O-TRIPHOSPHATE SODIUM SALT
• Synonyms: DTTP/DDTTP SODIUM SALT;3'-DEOXYTHYMIDINE-5'-O-TRIPHOSPHATE/2',3'-DIDEOXYTHYMIDINE-5'-O-TRIPHOSPHATE SODIUM SALT;3’-deoxythymidine-5’-o-triphosphate(dttp),sodiumsalt/2’,3’-dideoxythymidine-5’-o-triphosphate;3’-deoxythymidine5’-triphosphate*sodium;3'-DeoxythyMidine 5'-triphosphate sodiuM salt (ddTTP);3′-Deoxythymidine 5′-triphosphate sodium salt solution
• CAS NO: 128524-26-5
• Molecular Formula: C10H16N2O13P3.Na
• Molecular Weight: 488.149
• Mol File: 128524-26-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: 3'-DEOXYTHYMIDINE-5'-O-TRIPHOSPHATE/2',3'-DIDEOXYTHYMIDINE-5'-O-TRIPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-DEOXYTHYMIDINE-5'-O-TRIPHOSPHATE/2',3'-DIDEOXYTHYMIDINE-5'-O-TRIPHOSPHATE SODIUM SALT(128524-26-5)
• EPA Substance Registry System: 3'-DEOXYTHYMIDINE-5'-O-TRIPHOSPHATE/2',3'-DIDEOXYTHYMIDINE-5'-O-TRIPHOSPHATE SODIUM SALT(128524-26-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 128524-26-5(Hazardous Substances Data)

Usage

Uses

Used in Molecular Biology Research:
3'-Deoxythymidine-5'-O-triphosphate/2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is used as a substrate for DNA polymerases for the purpose of DNA synthesis and sequencing. The 3'-Deoxythymidine-5'-O-triphosphate provides the necessary building blocks for the elongation of DNA strands, whereas the 2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is employed in the Sanger sequencing method to terminate DNA chain growth at specific locations, allowing for the determination of the DNA sequence.
Used in DNA Sequencing:
In the field of DNA Sequencing, 3'-Deoxythymidine-5'-O-triphosphate/2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is used as a chain terminator to initiate the selective incorporation of ddNTPs at the desired positions in the DNA sequence. This process is crucial for the accurate determination of the order of nucleotides in a DNA molecule, which is fundamental to understanding genetic information.
Used in Diagnostics and Therapeutics Development:
3'-Deoxythymidine-5'-O-triphosphate/2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is also utilized in the development of diagnostic tools and therapeutics targeting DNA-related diseases. The ability to manipulate and sequence DNA with these compounds aids in the identification of genetic markers and the development of personalized medicine approaches.
Used in Forensic Science:
In Forensic Science, 3'-Deoxythymidine-5'-O-triphosphate/2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is used as a reagent in DNA profiling techniques such as DNA fingerprinting. This helps in the analysis of genetic material found at crime scenes to identify individuals or establish familial relationships.
Used in Synthetic Biology:
3'-Deoxythymidine-5'-O-triphosphate/2',3'-Dideoxythymidine-5'-O-triphosphate Sodium Salt is used as a component in the synthesis of artificial DNA sequences in synthetic biology. This allows researchers to create novel genetic constructs for various applications, including the design of organisms with specific functions or the development of biomaterials.