128524-45-8Relevant articles and documents
Eight micropeptins from a Microcystis spp. bloom collected from a fishpond near Kibbutz Lehavot HaBashan, Israel
Vegman, Margarita,Carmeli, Shmuel
, p. 10108 - 10115 (2013)
Eight new micropeptin-type cyclic depsipeptides, micropeptins LH920, LH1021, LH1048, LH1062, LH911A, LH911B, LH911C, and LH925, along with five known micropeptins, three known anabaenopeptins and two known microcystins (LR and RR), were isolated from a wa
Diketopiperazine derivatives from the marine-derived actinomycete Streptomyces sp. FXJ7.328
Wang, Pei,Xi, Lijun,Liu, Peipei,Wang, Yi,Wang, Wei,Huang, Ying,Zhu, Weiming
, p. 1035 - 1049 (2013)
Five new diketopiperazine derivatives, (3Z,6E)-1-N-methyl-3-benzy lidene-6-(2S-methyl-3-hydroxypropylidene)piperazine-2,5-dione (1), (3Z,6E)-1-N-methyl-3-benzylidene-6-(2R-methyl-3-hydroxypropylidene)piperazine-2, 5-dione (2), (3Z,6Z)-3-(4-hydroxybenzylid
Depsidomycins B and C: New cyclic peptides from a ginseng farm soil-derived actinomycete
Kwon, Yun,Byun, Woong Sub,Kim, Byung-Yong,Song, Myoung Chong,Bae, Munhyung,Yoon, Yeo Joon,Shin, Jongheon,Lee, Sang Kook,Oh, Dong-Chan
, (2018/06/06)
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess D-leucine, D-threonine, D-valine, and S-piperazic acid based on the advanced Marfey’s method and a GITC (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).
Mortiamides A-D, Cyclic Heptapeptides from a Novel Mortierella sp. Obtained from Frobisher Bay
Grunwald, Alyssa L.,Berrue, Fabrice,Robertson, Andrew W.,Overy, David P.,Kerr, Russell G.
supporting information, p. 2677 - 2683 (2017/11/06)
Four new cyclic heptapeptides, mortiamides A-D (1-4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey's method. Localization of l and d amino acids within each compound was ascertained by retention time comparison of the partial hydrosylate products of each compound to synthesized dipeptide standards using LC-HRMS. Compounds 1-4 did not exhibit any significant antimicrobial or cytotoxic activity.