1285486-55-6Relevant articles and documents
A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite
Mahajan, Sumit S.,Deu, Edgar,Lauterwasser, Erica M. W.,Leyva, Melissa J.,Ellman, Jonathan A.,Bogyo, Matthew,Renslo, Adam R.
, p. 415 - 419 (2012/01/04)
Hybrid drugs with a twist: The coupling of iron(II)-promoted trioxolane ring scission with a β-elimination reaction enables the targeted delivery of multiple drug activities to the malaria parasite. A prototypical fragmenting hybrid (shown) comprises an i