1285527-52-7Relevant academic research and scientific papers
A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid
Kaur, Rajbir,Khan, Sheema,Chib, Renu,Kaur, Tandeep,Sharma, Parduman Raj,Singh, Jaswant,Shah, Bhahwal Ali,Taneja, Subhash Chandra
, p. 1356 - 1366 (2011/04/24)
Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).
