1285534-36-2

Basic information

• Product Name: (E)-4-(4-(methylamino)phenyl)but-3-en-2-one
• Synonyms: (E)-4-(4-(methylamino)phenyl)but-3-en-2-one
• CAS NO: 1285534-36-2
• Molecular Weight: 175.23
• Mol File: 1285534-36-2.mol

Chemical Properties

• CAS DataBase Reference: (E)-4-(4-(methylamino)phenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(4-(methylamino)phenyl)but-3-en-2-one(1285534-36-2)
• EPA Substance Registry System: (E)-4-(4-(methylamino)phenyl)but-3-en-2-one(1285534-36-2)

Safety Data

• Hazardous Substances Data: 1285534-36-2(Hazardous Substances Data)

Upstream product

• 946-49-6 (E)-4-(4-nitrophenyl)-3-buten-2-one 
• 15753-85-2 (E)-4-(4-aminophenyl)but-3-en-2-one 
• 74-88-4 methyl iodide 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1285534-61-3 (1E,4E)-1-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)-5-(4-(methylamino)phenyl)penta-1,4-dien-3-one 
• 1285534-62-4 (1E,4E)-1-(4-(methylamino)phenyl)-5-(4-((2,2,3,3-tetramethyl-4,7,10-trioxa-3-siladodecan-12-yl)oxy)phenyl)penta-1,4-dien-3-one 
• 1285534-63-5 tert-butyl methyl(4-((1E,4E)-3-oxo-5-(4-((2,2,3,3-tetramethyl-4,7,10-trioxa-3-siladodecan-12-yl)oxy)phenyl)penta-1,4-dien-1-yl)phenyl)carbamate 
• 1285534-64-6 tert-butyl (4-((1E,4E)-5-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)-3-oxopenta-1,4-dien-1-yl)phenyl)(methyl)carbamate 
• 1285534-65-7 2-(2-(2-(4-((1E,4E)-5-(4-((tert-butoxycarbonyl)(methyl)amino)phenyl)-3-oxopenta-1,4-dien-1-yl)phenoxy)ethoxy)ethoxy)ethyl methanesulfonate 
• 1285534-71-5 C₂₄H₂₈⁽¹⁸⁾FNO₄ 
• 1285534-60-2 (1E,4E)-1-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)-5-(4-(methylamino)phenyl)penta-1,4-dien-3-one 
• 1285534-40-8 (1E,4E)-1-(4-bromophenyl)-5-(4-(methylamino)phenyl)penta-1,4-dien-3-one 
• 1285534-44-2 (1E,4E)-1-(4-iodophenyl)-5-(4-(methylamino)phenyl)penta-1,4-dien-3-one 

Relevant articles and documents

Novel 18F-labeled dibenzylideneacetone derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques

A series of dibenzylideneacetones were synthesized and evaluated as imaging probes for β-amyloid plaques. They displayed high binding affinity to Aβ1-42 aggregates (Ki = 6.4 for 8, Ki = 3.0 for 9), and the high binding wer

Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for ?-Amyloid Plaques

A new and extensive set of dibenzylideneacetone derivatives was synthesized and screened for affinity toward A1-42 aggregates. Structure-activity relationships revealed the binding of dibenzylideneacetones to be affected by various substituents. The introduction of a substituent group in the ortho position reduced or abolished the binding. However, the para position was highly tolerant of sterically demanding substitutions. Three radioiodinated ligands (6, 70, and 71) and two 18F fluoro-pegylated (FPEG) ligands (83 and 85) were prepared, all of which displayed high affinity for A1-42 aggregates (Ki ranging from 0.9 to 7.0 nM). In biodistribution experiments, they exhibited good initial penetration (1.59, 4.68, 4.56, 4.13, and 5.15% ID/g, respectively, at 2 min) of and fast clearance from the brain. Autoradiography with sections of postmortem AD brain and transgenic mouse brain confirmed the high affinity of these tracers. These preliminary results strongly suggest the dibenzylideneacetone structure to be a potential new scaffold for β-amyloid imaging probes.